Extracellular regulation of metalloproteinases
نویسندگان
چکیده
منابع مشابه
Regulation of matrix metalloproteinases in human endometrium.
Considerable evidence supports a role for matrix metalloproteinases (MMP) in menstruation, but their focal pattern of expression within perimenstrual and menstrual endometrium suggests local rather than hormonal regulation. Menstruation shares a number of features with inflammatory responses, with leukocyte infiltration, proliferation and activation, occurring in the endometrium prior to menstr...
متن کاملIntegrin receptor signaling and matrix metalloproteinases regulation
Integrins play a significant role in the acquisition of a neoplastic phenotype through their ability to induce cell proliferation and prevent apoptosis. Complex alterations in the integrin expression profile, including upor downregulation, are associated with tumorigenesis. It is currently generally accepted that the combined participation of integrins and matrix metalloproteinases (MMPs) is es...
متن کاملThe Extracellular Matrix, Matrix Metalloproteinases and their roles in Disease
Biomedical research is often thought to primarily focus upon the trillions of cells that make up the body. However just as study of the immune system cannot ignore the lymph in favor of blood, the extracellular matrix (ECM) cannot be ignored in favor of the cells. The ECM is a dynamic structure that acts as scaffolding substrate for cell adhesion, as well as a reservoir of various proteins, gro...
متن کاملExtracellular regulation of BMP signaling
In the developing organism, cells differentiate, divide and die as part of groups of hundreds or thousands of cells called 'morphogenetic fields'. Fields have the remarkable property of self-regulation: for example, if the forelimb field is bisected, each half can give rise to a complete limb after transplantation, as discovered by Ross Harrison in 1918. Therefore, cells in the morphogenetic fi...
متن کاملThe regulation of matrix metalloproteinases and their inhibitors.
The matrix metalloproteinases (MMP) are a family of 23 enzymes in man. These enzymes were originally described as cleaving extracellular matrix (ECM) substrates with a predominant role in ECM homeostasis, but it is now clear that they have much wider functionality. Control over MMP and/or tissue inhibitor of metalloproteinases (TIMP) activity in vivo occurs at different levels and involves fact...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Matrix Biology
سال: 2015
ISSN: 0945-053X
DOI: 10.1016/j.matbio.2015.02.007